Levobunolol (AK-Beta, Liquifilm, Betegan) je neselektivni beta blokator. On se koristi topikalno za tretiranje glaukoma.
Levobunolol
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| (IUPAC) ime
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| (S)-5[3-(tert-butilamino)-2-hidroksipropil]oksi3,4-dihidronaftalen-1(2H)-on
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| Klinički podaci
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| Robne marke
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Betagan
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| AHFS/Drugs.com
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Monografija
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| MedlinePlus
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a686011
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| Identifikatori
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| CAS broj
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47141-42-4
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| ATC kod
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S01ED03
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| PubChem[1][2]
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39468
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| DrugBank
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DB01210
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| ChemSpider[3]
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36089
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| UNII
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G6317AOI7K  Y
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| KEGG[4]
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D08115 Y
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| ChEBI
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CHEBI:6438 Y
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| ChEMBL[5]
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CHEMBL1201237 Y
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| Hemijski podaci
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| Formula
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C17H25NO3
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| Mol. masa
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291,385 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1 Y
Key: IXHBTMCLRNMKHZ-LBPRGKRZSA-N Y |
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| Farmakokinetički podaci
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| Poluvreme eliminacije
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20 sata
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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℞-only (SAD)
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| Način primene
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Topikalno (kapi za oči)
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- Ishibashi T, Yokoi N, Kinoshita S (2003). „Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface.”. Cornea 22 (8): 709–15. DOI:10.1097/00003226-200311000-00001. PMID 14576520.
- Ogasawara H, Yoshida A, Fujio N, Konno S, Ishiko S (1999). „[Effect of topical levobunolol on retinal, optic nerve head, and choroidal circulation in normal volunteers]”. Nippon Ganka Gakkai Zasshi 103 (7): 544–50. PMID 10443129.
- Leung M, Grunwald J (1997). „Short-term effects of topical levobunolol on the human retinal circulation.”. Eye 11 (3): 371–6. DOI:10.1038/eye.1997.78. PMID 9373479.
