Sarah Yip, PhD
Associate Professor of PsychiatryCards
About
Research
Publications
Featured Publications
Distinct neural networks predict cocaine versus cannabis treatment outcomes
Lichenstein S, Kohler R, Ye F, Potenza M, Kiluk B, Yip S. Distinct neural networks predict cocaine versus cannabis treatment outcomes. Molecular Psychiatry 2023, 28: 3365-3372. PMID: 37308679, PMCID: PMC10713861, DOI: 10.1038/s41380-023-02120-0.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingCognitive behavior therapyCognitive behavioral therapySubstance use disordersCannabis abstinenceNeural mechanismsBehavior therapyDistinct neural networksComputer-based trainingCannabis use disorderFMRI scanningNeural predictorsStudy 1Study 2Treatment outcomesContingency managementPrior workComparison subjectsNetwork strengthUse disordersNovel treatment targetsAbstinenceIndependent samplesCocaine abstinenceTreatment respondersEmerging Topics in Computational Psychiatric Research: Clarity Through Complexity?
Yip S, Konova A. Emerging Topics in Computational Psychiatric Research: Clarity Through Complexity? Biological Psychiatry 2023, 93: 652-654. PMID: 36948759, DOI: 10.1016/j.biopsych.2023.02.005.Peer-Reviewed Original Research
2025
Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder
Ye J, Mehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder. JAMA Network Open 2025, 8: e2455165. PMID: 39821393, PMCID: PMC11742521, DOI: 10.1001/jamanetworkopen.2024.55165.Peer-Reviewed Original ResearchConceptsDecreased cognitive controlCognitive controlOpioid use disorderCueing paradigmResting-stateHC participantsUse disorderBrain statesBrain dynamicsHealthy controlsNeural mechanismsCognitive processesNeural variabilityFMRIBehavioral implicationsImpaired abilityBrainAccuracy scoresMagnetic resonance imagingDynamic alterationsParticipantsCase-control studyDisordersParadigmImpacts millions
2024
Considering the interconnected nature of social identities in neuroimaging research
Dhamala E, Ricard J, Uddin L, Galea L, Jacobs E, Yip S, Yeo B, Chakravarty M, Holmes A. Considering the interconnected nature of social identities in neuroimaging research. Nature Neuroscience 2024, 1-12. PMID: 39730766, DOI: 10.1038/s41593-024-01832-y.Peer-Reviewed Original ResearchStudy of psychiatric conditionsComplex human behaviorNeuroimaging researchNeuroimaging studiesPsychiatric conditionsBehavioral expressionStudy of behaviorBrain biologyMental health domainsIllness expressionDiverse intersectional identitiesMental healthSociodemographic factorsTreatment responseLife experiencesIndividual variabilityIntersectional identitiesHuman behaviorSocial identityHealth domainsNature of social identitySymptom burdenNeuroimagingParticipant recruitmentBrainBayesian subtyping for multi-state brain functional connectome with application on preadolescent brain cognition
Chen T, Zhao H, Tan C, Constable T, Yip S, Zhao Y. Bayesian subtyping for multi-state brain functional connectome with application on preadolescent brain cognition. Biostatistics 2024, kxae045. PMID: 39656842, DOI: 10.1093/biostatistics/kxae045.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentVariational inference algorithmApproximate posterior inferenceFunctional connectivityMultiple cognitive statesInference algorithmExtensive simulationsNetwork topologyNetwork featuresFunctional network patternsBrain functional connectomeBrain functional connectivityEstimation accuracySubgroups of individualsNeurobiological heterogeneityCognitive profileCognitive statesConverging evidencePosterior inferenceDetection alternativesNeuroscience literatureBrain cognitionFunctional connectomeNetworkCognitive developmentAlterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder.
Mehta S, Peterson H, Ye J, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Jeon S, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D, Weintraub E. Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder. Radiology 2024, 313: e240514. PMID: 39656127, DOI: 10.1148/radiol.240514.Peer-Reviewed Original ResearchConceptsHealthy control participantsRight medial temporal lobeOpioid use disorderFunctional brain alterationsMedial temporal lobeOpioid use disorder groupFunctional connectivityUse disorderControl participantsBrain alterationsIntrinsic resting-state functional connectivityTemporal lobeMedial prefrontal cortex volumesVoxel-wise linear regressionT1-weighted MRIResting-state functional connectivityFamily-wise error correctionPrefrontal cortex volumeResting-state functional MRIIncreased functional connectivityIntrinsic connectivity distributionFunctional MRI studiesFemale participantsRegional brain volumesAssess group differencesPrediction of craving across studies: A commentary on conceptual and methodological considerations when using data-driven methods
Antons S, Yip S, Lacadie C, Dadashkarimi J, Scheinost D, Brand M, Potenza M. Prediction of craving across studies: A commentary on conceptual and methodological considerations when using data-driven methods. Journal Of Behavioral Addictions 2024, 13: 695-701. PMID: 39356557, PMCID: PMC11457034, DOI: 10.1556/2006.2024.00050.Peer-Reviewed Original ResearchConceptsAddictive behaviorsDisorders due to addictive behaviorsConnectome-based predictive modelingPrediction of cravingInvestigate neural mechanismsSubstance use disordersNeural mechanismsCravingSubstance useMethodological considerationsDisordersMethodological featuresBehaviorConceptualizationCommentaryStudyFindingsSubstancesA shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities
Ricard J, Labache L, Segal A, Dhamala E, Cocuzza C, Jones G, Yip S, Chopra S, Holmes A. A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities. Communications Biology 2024, 7: 1178. PMID: 39300138, PMCID: PMC11413242, DOI: 10.1038/s42003-024-06836-9.Peer-Reviewed Original ResearchConceptsCocaine use disorderPatterns of functional connectivityUse disorderFunctional connectivityReceptor densityLarge-scale functional brain networksMaintenance of substance useDopamine D2/3 receptorsDopamine receptor densityCortico-striatal circuitsProfile of functional connectivitySubstance use disordersFunctional brain networksNeurotransmitter receptor densityD2/3 receptorsDopamine systemTransporter bindingSubcortical systemsBrain networksSubstance useCocaineSpatial topographyDisordersDopamineBiological mechanismsCOCAINE SELF-ADMINISTRATION BEHAVIOR IS ASSOCIATED WITH SUBCORTICAL AND CORTICAL GRAY MATTER IN INDIVIDUALS WITH COCAINE USE DISORDER
Kohler R, Zhornitsky S, Potenza M, Yip S, Worhunsky P, Angarita G. COCAINE SELF-ADMINISTRATION BEHAVIOR IS ASSOCIATED WITH SUBCORTICAL AND CORTICAL GRAY MATTER IN INDIVIDUALS WITH COCAINE USE DISORDER. Drug And Alcohol Dependence 2024, 260: 110081. DOI: 10.1016/j.drugalcdep.2023.110081.Peer-Reviewed Original ResearchW147 Neural and Behavioral Habituation to Sad Infant Stimuli in Mothers who Use Substances
McCurdy L, Yip S, Worhunsky P, Kim S, Strathearn L, Potenza M, Mayes L, Rutherford H. W147 Neural and Behavioral Habituation to Sad Infant Stimuli in Mothers who Use Substances. Drug And Alcohol Dependence 2024, 260: 110848. DOI: 10.1016/j.drugalcdep.2023.110848.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Connectivity While Coming of Age
HIC ID2000028368RoleSub InvestigatorPrimary Completion Date12/31/2026Recruiting ParticipantsGenderBothAge18 years - 25 yearsImaging Synaptic Density in Cocaine and Opiate Addiction In Vivo using 11C-UCB-J PET
HIC ID2000021843RoleSub InvestigatorPrimary Completion Date01/01/2024Recruiting Participants
News
News
- February 06, 2025Source: Biological Psychiatry
Identification and External Validation of a Problem Cannabis Risk Network
- October 09, 2024
Yip Elected to Board of Directors of APT Foundation
- August 29, 2024
Yale Researchers Awarded $20.6M Grant for Wide-Ranging Study of Mental Illness
- April 22, 2024
Mentorship and Science