(Q36485086)

14 August 2017

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title

Pharmacology of current and promising nucleosides for the treatment of human immunodeficiency viruses (English)

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14 August 2017

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1

Raymond F Schinazi

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Brenda I Hernandez-Santiago

14 August 2017

series ordinal

2

object named as

Brenda I Hernandez-Santiago

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14 August 2017

Selwyn J Hurwitz

3

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14 August 2017

publication date

18 April 2006

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14 August 2017

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14 August 2017

volume

71

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14 August 2017

issue

2-3

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14 August 2017

page(s)

322-334

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The time of administration of 3'-azido-3'-deoxythymidine (AZT) determines its host toxicity with possible relevance to AZT chemotherapy

14 August 2017

cites work

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https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Treatment for adult HIV infection: 2004 recommendations of the International AIDS Society-USA Panel.

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https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

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https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 2',3'-dideoxynucleoside analogs in resting and activated human cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Determining the antiviral activity of tenofovir disoproxil fumarate in treatment-naive chronically HIV-1-infected individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

New antiretroviral drugs

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https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Anti-HIV drug development--an overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Enhanced binding of azidothymidine-resistant human immunodeficiency virus 1 reverse transcriptase to the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Antiretroviral drugs for AIDS.

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https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

The impact of the M184V substitution in HIV-1 reverse transcriptase on treatment response

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Clinical pharmacokinetics of zidovudine. An overview of current data

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L-FMAU, DAPD, penciclovir and lobucavir

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Effect of oral administration of emtricitabine on woodchuck hepatitis virus replication in chronically infected woodchucks

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Abacavir: a review of its clinical potential in patients with HIV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Drug resistance and virologic response in NUCA 3001, a randomized trial of lamivudine (3TC) versus zidovudine (ZDV) versus ZDV plus 3TC in previously untreated patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Population pharmacokinetics of nevirapine, zidovudine, and didanosine in human immunodeficiency virus-infected patients. The National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Antiretroviral therapy in adults: updated recommendations of the International AIDS Society-USA Panel

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Indinavir concentrations and antiviral effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacokinetic and pharmacodynamic characteristics of emtricitabine support its once daily dosing for the treatment of HIV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Toxicity, efficacy, plasma drug concentrations and protease mutations in patients with advanced HIV infection treated with ritonavir plus saquinavir

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Drug resistance and drug combination features of the human immunodeficiency virus inhibitor, BCH-10652 [(+/-)-2'-deoxy-3'-oxa-4'-thiocytidine, dOTC].

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2‘,3‘-dideoxycytidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Anti-HIV activity of (-)-(2R,4R)-1- (2-hydroxymethyl-1,3-dioxolan-4-yl)-thymine against drug-resistant HIV-1 mutants and studies of its molecular mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Anti-HIV-1 activities of 1,3-dioxolane guanine and 2,6-diaminopurine dioxolane

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacodynamic effects of zidovudine 600 mg once/day versus 300 mg twice/day in therapy-naïve patients infected with human immunodeficiency virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Lamivudine 300 mg QD versus continued lamivudine 150 mg BID with stavudine and a protease inhibitor in suppressed patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacologic considerations for therapeutic success with antiretroviral agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter. AIDS Clinical Trials Group Study 175 Study Team

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacokinetics of (-)-beta-D-dioxolane guanine and prodrug (-)-beta-D-2,6-diaminopurine dioxolane in rats and monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Lamivudine‐Resistant Human Immunodeficiency Virus Type 1 Variants (184V) Require Multiple Amino Acid Changes to Become Co‐Resistant to Zidovudine In Vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondri

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Lamivudine as initial treatment for chronic hepatitis B in the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Phase i/ii trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in human immunodeficiency virus-infected adults

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Characterization of a dCTP transport activity reconstituted from human mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Cellular nucleoside pharmacokinetics and pharmacology: a potentially important determinant of antiretroviral efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Human immunodeficiency virus reverse transcriptase. Substrate and inhibitor kinetics with thymidine 5'-triphosphate and 3'-azido-3'-deoxythymidine 5'-triphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5'-phosphates by mammalian phosphotransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Circadian rhythm of rat spleen cytoplasmic thymidine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacokinetics of emtricitabine, didanosine and efavirenz administered once-daily for the treatment of HIV-infected adults (pharmacokinetic substudy of the ANRS 091 trial).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacologic characteristics of indinavir, didanosine, and stavudine in human immunodeficiency virus-infected children receiving combination therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Equivalent steady-state pharmacokinetics of lamivudine in plasma and lamivudine triphosphate within cells following administration of lamivudine at 300 milligrams once daily and 150 milligrams twice daily

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Population pharmacokinetics of tenofovir in human immunodeficiency virus-infected patients taking highly active antiretroviral therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Virologic and immunologic benefits of initial combination therapy with zidovudine and zalcitabine or didanosine compared with zidovudine monotherapy. Wellcome Resistance Study Collaborative Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Emtricitabine/tenofovir disoproxil fumarate

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Population pharmacokinetics of lamivudine in adult human immunodeficiency virus-infected patients enrolled in two phase III clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

DAPD (Emory University/Triangle Pharmaceuticals/Abbott Laboratories).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

3'-Azido-3'-deoxythymidine inhibits globin gene transcription in butyric acid-induced K-562 human leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Combinations of nucleoside/nucleotide analogues for HIV therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacokinetic properties of nucleoside/nucleotide reverse transcriptase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Tenofovir disoproxil fumarate: a review of its use in the management of HIV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

New nucleoside/nucleotide backbone options: a review of recent studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

In vitro activity of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor (NRTI), against 215 HIV-1 isolates resistant to other NRTIs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Short-term safety and pharmacodynamics of amdoxovir in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Antiretrovirals, Part II: focus on non-protease inhibitor antiretrovirals (NRTIs, NNRTIs, and fusion inhibitors).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Treatment with lamivudine, zidovudine, or both in HIV-positive patients with 200 to 500 CD4+ cells per cubic millimeter. North American HIV Working Party

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

A long-term latent reservoir for HIV-1: discovery and clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Comparative pharmacokinetics of Racivir, (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats, rabbits, dogs, monkeys and HIV-infected humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

The pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells from patients infected with HIV-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Comparative effects of 3'-azido-3'-deoxythymidine and its metabolite 3'-amino-3'-deoxythymidine on hemoglobin synthesis in K-562 human leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Extended lamivudine retreatment for chronic hepatitis B: maintenance of viral suppression after discontinuation of therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Single-dose pharmacokinetics and safety of abacavir (1592U89), zidovudine, and lamivudine administered alone and in combination in adults with human immunodeficiency virus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Enzymatic assay for measurement of intracellular DXG triphosphate concentrations in peripheral blood mononuclear cells from human immunodeficiency virus type 1-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacokinetic variability of zidovudine in HIV-infected individuals: subgroup analysis and drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Population pharmacokinetics and pharmacodynamic modeling of abacavir (1592U89) from a dose-ranging, double-blind, randomized monotherapy trial with human immunodeficiency virus-infected subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Mechanisms of HIV and nucleoside reverse transcriptase inhibitor injury to mitochondria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

A pilot study of low-dose zidovudine in human immunodeficiency virus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

In vivo antagonism with zidovudine plus stavudine combination therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Quantitation of intracellular triphosphate of emtricitabine in peripheral blood mononuclear cells from human immunodeficiency virus-infected patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Clinical pharmacokinetics of lamivudine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Zidovudine update: 1990.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Population pharmacokinetics of zidovudine. The Veterans Administration Cooperative Studies Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Inhibition of beta-globin gene expression by 3'-azido-3'-deoxythymidine in human erythroid progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

New nucleoside reverse transcriptase inhibitors for the treatment of HIV infections

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Safety, pharmacokinetics, and efficacy of (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine with efavirenz and stavudine in antiretroviral-naïve human immunodeficiency virus-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Anti-Human Immunodeficiency Virus Activity and Cellular Metabolism of a Potential Prodrug of the Acyclic Nucleoside Phosphonate 9- R -(2-Phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

3'-Azido-3'-deoxythymidine inhibits erythroid-specific transcription factors in human erythroid K562 leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Dual efficacy of lamivudine treatment in human immunodeficiency virus/hepatitis B virus-coinfected persons in a randomized, controlled study (CAESAR). The CAESAR Coordinating Committee

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Scientific rationale for antiretroviral therapy in 2005: viral reservoirs and resistance evolution.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Evidence for prolonged clinical benefit from initial combination antiretroviral therapy: Delta extended follow-up

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

The bottleneck in AZT activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Intracellular nucleotides of (-)-2',3'-deoxy-3'-thiacytidine in peripheral blood mononuclear cells of a patient infected with human immunodeficiency virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Once-daily versus twice-daily lamivudine, in combination with zidovudine and efavirenz, for the treatment of antiretroviral-naive adults with HIV infection: a randomized equivalence trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Potent antiviral effect of reverset in HIV-1-infected adults following a single oral dose.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacokinetics, oral bioavailability, and metabolism in mice and cynomolgus monkeys of (2'R,5'S-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, an agent active against human immunodeficiency virus and human hepatitis B virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Emtricitabine: an antiretroviral agent for HIV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Accumulation of mitochondrial DNA mutations in human immunodeficiency virus-infected patients treated with nucleoside-analogue reverse-transcriptase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

In vitro antiretroviral activity and in vitro toxicity profile of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor for treatment of human immunodeficiency virus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Once-daily abacavir in place of twice-daily administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Mechanism of action and in vitro activity of 1',3'-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients for whom standard nucleoside therapy fails

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Biotransformation and pharmacokinetics of prodrug 9-(β-d-1,3-dioxolan-4-yl)-2-aminopurine and its antiviral metabolite 9-(β-d-1,3-dioxolan-4-yl)guanine in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Safety and efficacy of lamivudine-zidovudine combination therapy in zidovudine-experienced patients. A randomized controlled comparison with zidovudine monotherapy. Lamivudine European HIV Working Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

The pharmacology of antiretroviral nucleoside and nucleotide reverse transcriptase inhibitors: implications for once-daily dosing

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16716415

12 December 2020

10.1016/J.ANTIVIRAL.2006.03.012

Identifiers

DOI

1 reference

14 August 2017

1 reference